--- title: "Potassium & Adrenal Function" date: 2019-12-01 tags: [data science, r, nutrition] excerpt: "A Data Science Approach to Optimal Nutrition." ---
By now it is pretty well-established that the Standard American Diet (SAD) is a suboptimal approach to adequate nutrition. One area where this is exceptionally pronounced is in potassium intake. Less than 2% of Americans achieve the recommended daily intake of potassium (4700mg), which is most likely the result of not consuming enough greens. When i’ve brought these numbers up with friends, a common question is: “How much potassium is there in a banana??” For reference, your typical banana contains about 300mg of Potassium, so unless you’re eating around 15 bananas a day, you’re probably not aware of how much you really need for your body to function appropriately. In general, the reason I felt compelled to look into this in the first place was because I noticed being more anxious than usual, especially at times when I shouldn’t have been. Before heading to a physician, it’s important to self-reflect by ruling out obvious (e.g. lack of adequate sleep) and not so obvious (lack of adequate nutrition) culprits in your lifestyle. With respect to the latter, I really wasn’t sure. What would a nutritionist say about this? A guiding principle in situations like this is to make sure that the body’s hardware is properly maintained before pathologizing it’s software.
A fascinating relationship appears to exist between adrenal function and potassium levels in the body. Studies have shown that cortisol (i.e., the stress hormone) and potassium levels are negatively correlated. Personally, I think a widely neglected factor contributing to such unnatural spikes in cortisol - aside from the lack of adequate vegetable consumption - is excessive caffeine intake [1]. Caffeine has been shown to undesirably stimulate the adrenals, such that levels of cortisol after caffeine consumption are similar to those experienced during an acute stress response. As a grad student, i’ll be the first to admit that I drink wayyyy too much coffee. Potassium, on the other hand, appears to have a calming effect on the body and is even referred to as the body’s “natural tranquilizer” based on how it aides the parasympathetic nervous system. In fact, potassium bromide was once used as a sedative for clinical patients and even as an anti-convulsant to treat epilepsy [2]. In any event, it’s reasonable to expect that the combination of elevated cortisol and depleted potassium can’t be good for your body. This combination can potentially lead your body into a chronically active fight-or-flight state, which essentially makes all of your vital organs hyper-excitable. Indeed, one of the primary characteristics of an unhealthy adrenal is irritability and anxiety. Once you factor in the elevated cholesterol levels that often accompany the SAD diet, the body’s circulation system could be a real mess [3]. This collection of symptoms characterizes a problem that some clinicians consider as “Adrenal Fatigue”. What are some ways to counteract these mechanisms and get closer to the 4700mg recommendation? Let’s see if we can use some data to answer this question using a publicly available dataset provided from the U.S. Agricultural Research Service Food Data Central.
The plot aboveis a “heatmap” that displays the correlations between nutrition contents as a pixellated image. The blue-ish pixels in the image represent positive correlations, and vice versa for red-ish pixels. When you zoom in on the image, you can see how foods that are high in potassium tend to also be high in other vital nutrients like Iron, Fiber, and Magnesium. For me, this makes sense because i’ve come across so may articles or videos that discuss the nutritional value of each of these minerals, and often times it sounds like they have highly overlapping roles in the body. Let’s take a closer look at the group containing potassium.
What I wanted to do next was to look at the foods that we’re loaded with these nutrients. But first, we should scale the nutrient contents by their recommended daily intake (RDI) values to make them comparable. As mentioned before, the RDI for potassium is 4700mg so let’s take a look at which food categories fall into the upper 90th percentile of RDI values for potassium - which tends to be in the 10-20% RDI range. The pie chart below gives us this information, and it’s no surprise that vegetables are a big chunk of the pie:
If we’re interested in making a dietary recommendation, I think it’s easiest to work with products that can be easily thrown into a blender for a smoothie. So let’s look at the following 3 categories: (1) Nut and Nut products, (2) Fruits and Fruit Juices, (3) and Vegetable and Vegetable products. What are some products that fall into this category of high-potassium foods? We can use a “Word Cloud” to visualize the most common words found in these foods items, after removing those that fall out side of the 10-20% RDI range. Here’s what that looks like for each of the 3 categories of interest:
The word cloud on the top-left shows the potassium-rich foods found in the Nut and Nut Products while the cloud on the top-right shows those that are found in Fruit and Fruit Juices. The cloud on the bottom shows Vegetable and Vegetable Prodcuts and is a lot larger since most potassium-rich foods tend to fall in this category of foods. These plots aren’t perfect - you can easily spot some uninformative adjective words (e.g., “Chinese”, “European”, “pealed”, “dried”, etc). Also, the size of the words are not actually weighted by potassium content. Rather, theses are simply words that are most commonly listed in the table of high-potassium foods (e.g. Kale definitely has more potassium than a potato). But you can nonetheless get a good idea of the foods found in each category. What stands out to me most is how the beloved banana is absent in these results, while the plantain is not. This method also confirms what we had expected to be true all along: Avocados are God’s gift to humankind.
Considering how many of the nutrients are correlated with each other (as shown above), it makes sense to treat potassium as part of a multi-dimensional nutritional construct. I’d find it useful to have some metric that combines the Iron, Magnesium, Fiber, and Potassium contents found in the individual food items to tell us how much of that combination that food has available, rather than just consider potassium by itself. Using a popular approach called principal components analysis (PCA), we can rank foods on the basis of their combined Potassium/Iron/Magnesium/Fiber contents:
The bar plot above shows us all of the foods that are rich in potassium, but ordered according to how much additional nutrients they carry. The bars on the far right are the ones that give you the most bang for your buck, while the ones are the far left are foods that are concentrated with potassium in a one-dimensional manner. Hovering your cursor over each individual bar will give you the food’s name along with its nutrient RDI percentage (RDI Magnesium: 420mg, RDI Iron: 8mg, RDI Fiber: 38g). I’ve included their sugar contents since it’s ideal to stay away from foods that are packed with sugar. Fruits are highly nutritious but, unfortunately, are loaded with sugar. Take for example, the purple bar on the far-right: Medjool dates. Although these dates are a great source of the nutrients, they contain 132% of your recommended daily intake for sugar. This is a ridiculous amount and i’d say a food like this is best kept avoided. In contrast, california avocado’s (the 4th purple bar from the right) is loaded with great contents and has nearly 0% sugar. Again, avocados - especially from California - are just flat out impressive.One food that isn’t represented in this analysis but serves as a fantastic beverage to use in smoothies is coconut water. It typically contains about 500mg of potassium (10% of RDI) per serving (i.e., more than a banana) and tastes delicious. I’d go with any brand that minimizes the added sugars. Personally, I like to blend some coconut water, kale (10%), an avacodo (11%), and a banana (6%) with some ice to make a delicious smoothie to get me going. Optional: add a scoop of a plant-based coconut-almond protein powder (6%) from wholefoods into the mix and the resulting taste is just outstanding. Importantly though, a smoothie like this not only gets you to nearly 50% of the RDI for potassium, but also has so many other nutrients to cover your bases in those areas as well which is great.
The rest of your daily needs can easily be satisfied through healthy snacks like chestnuts or brazilnuts, or through a nice side-salad with your meals (e.g.,Kale, Spinach, Taro leaves, Brussel Sprouts).